Publications

Original papers

Review

Original papers

2018

Development of ultra-thin chips for immobilization of Caenorhabditis elegans in microfluidic channels during irradiation and selection ofbuffer solution to prevent dehydration. Suzuki M, Sakashita T, HattoriY, Yokota Y, Kobayashi Y, Funayama T. J Neurosci Methods. 2018 Aug1;306:32-37

2017

Region-specific irradiation system with heavy-ion microbeam for activeindividuals of Caenorhabditis elegans. Suzuki, M., Hattori, Y.,Sakashita, T., Yokota, Y., Kobayashi, Y. & Funayama, T., J. Radiat. Res.58: 881-886, 2017.

Abscopal Activation of Microglia in Embryonic Fish Brain FollowingTargeted Irradiation with Heavy-Ion Microbeam. Yasuda, T., Kamahori, M.,Nagata, K., Watanabe-Asaka, T., Suzuki, M., Funayama, T., Mitani, H. &Oda, S., Int J Mol Sci 18: 1428, 2017.

Histone deacetylase inhibitors sensitize murine B16F10 melanoma cells tocarbon ion irradiation by inducing G1 phase arrest. Saito, K., Funayama,T., Yokota, Y., Murakami, T. & Kobayashi, Y., Biol Pharm Bull 40:844-851, 2017.

An Estimation Method for Environmental Friction Based on Body DynamicModel of Caenorhabditis elegans. Soh, Z., Suzuki, M. & Tsuji, T.,J Robot Network Artificial Life, 4: 32-40, 2017.

A correlation of long term effects and radiation quality in the progenyof bystander cells after microbeam radiations: The experimental study ofradiotherapy for cancer risk mitigation. Autsavapromporn, N., Konishi,T., Liu, C., Plante, I., Funayama, T., Usami, N., Azzam, E. I. & Suzuki,M., J Phys Conf Ser 860: 012026, 2017.

2016

In vivo 3D analysis of systemic effects after local heavy-ionbeam irradiation in an animal model. Nagata, K., Hashimoto, C., Watanabe-Asaka, T., Itoh, K., Yasuda, T.,Ohta, K., Oonishi, H., Igarashi, K., Suzuki, M., Funayama, T.,Kobayashi, Y., Nishimaki, T., Katsumura, T., Oota, H., Ogawa, M., Oga,A., Ikemoto, K., Itoh, H., Kutsuna, N., Oda, S. & Mitani, H. Sci Rep 6,28691, 2016.

2015

Nitric oxide-mediated bystander signal transductions induced by heavy-ion microbeam irradiation Life Sciences in Space Research. Tomita M, Matsumoto H, Funayama T, Yokota Y, Otsuka K, Maeda M, Kobayashi Y, Life Sci Space Res, 6, 36-43, 2015.

The bystander cell-killing effect mediated by nitric oxide in normal human fibroblasts varies with irradiation dose but not with radiation quality. Yokota Y, Funayama T, Mutou-Yoshihara Y, Ikeda H, Kobayashi Y, Int J Radiat Biol, 91(5), 383-388, 2015.

A mathematical model of the radiation-induced responses in cellular population including cell-to-cell communications. Hattori Y, Suzuki M, Funayama T, Kobayashi Y, Yokoya A and Watanabe R, Radiat Prot Dosimetry, 166, 142-147, 2015.

Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: The relevance to cancer risk. Autsavapromporn N, Plante I, Liu C, Konishi T, Usami N, Funayama T, Azzam E I, Murakami T & Suzuki M, Int J Radiat Biol, 91(1), 62-70, 2015.

2014

Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation. Takahashi A, Kubo M, Hongyu Ma, Nakagawa A, Yoshida Y, Isono M, Kanai T, Ohno T, Furusawa Y, Funayama T, Kobayashi Y and Nakano T, Radiat Res, 182(3), 338-344, 2014.

A branching process model for the analysis of abortive colony size distributions in carbon ion-irradiated normal human fibroblasts. Sakashita T, Hamada N, Kawaguchi I, Hara T, Kobayashi Y, Saito K, J Radiat Res, 55(3), 423-431, 2014.

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells. Murata K, Noda S, Oike T, Takahashi A, Yoshida Y, Suzuki Y, Ohno T, Funayama T, Kobayashi Y, Takahashi T, Nakano T, J Radiat Res, 55(4), 658-664, 2014.

2013

Gap Junction Communication and the Propagation of Bystander Effects Induced by Microbeam Irradiation in Human Fibroblast Cultures: The Impact of Radiation Quality. Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou, Y, Ikeda H, Kobayashi K, Kobayashi Y, Uchihori Y, Hei T K, Azzamg E I & Murakami T, Radiat Res, 180(4), 367-375, 2013.

A framework for analysis of abortive colony size distributions using a model of branching processes in irradiated normal human fibroblasts. Sakashita T, Hamada N, Kawaguchi I, Ouchi NB, Hara T, Kobayashi Y, Saito K, PLoS ONE, 2013, 8, e70291.

Effects of Ion Beam Irradiation on the Expression of Glutathione Peroxidase in Cultured Human Retinal Vascular Endothelial Cells Exposed to L-dopa. Akeo K, Hamada N, Funayama T, Akeo Y, Kobayashi Y, Tiss Cult Res Commun, 32, 195-202, 2013.

2012

Innate immune genes including a mucin-like gene, mul-1, induced by ionizing radiation in Caenorhabditis elegans. Kimura T, Takanami T, Sakashita T, Wada S, Kobayashi Y, Higashitani A, Radiat Res. 178, 313-320, 2012.

Effects of low- and high-LET radiation on the salt chemotaxis learning in Caenorhabditis elegans. Sakashita T, Suzuki M, Hamada N, Shimozawa Y, Shirai-Fukamoto K, Yokota Y, Hamada-Sora S, Kakizaki T, Wada S, Funayama T, Kobayashi Y, Biol Sci Space, 26, 21-25, 2012.

.Electron-spin relaxation phenomena in irradiated saccharides detected by pulsed electron paramagnetic resonance spectroscopy. Kikuchi M, Kameya H, Shimoyama Y, Ukai M, Kobayashi Y, Radiat Phys Chem, 81(10), 1639-1645, 2012.

Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells. Musha A, Yoshida Y, Takahashi,T, Ando ., Funayama T, Kobayashi Y, Negishi A, Yokoo S & Nakano T, J Radiat Res, 53(4), 545-550, 2012.

Behavioral resistance of Caenorhabditis elegans against high-LET radiation exposure. Sakashita T, Suzuki M, Hamada N, Shimozawa Y, Shirai-Fukamoto K, Yokota Y, Hamada-Sora S, Kakizaki T, Wada S, Funayama T, Kobayashi Y, Biol Sci Space, 26, 7-11, 2012.

Involvement of bystander effect in suppression of the cytokine production induced by heavy-ion broad beams. Mutou-Yoshihara Y, Funayama T, Yokota Y and Kobayashi Y, Int J Radiat Biol, 88(3), 258-266, 2012. 

Tolerance of anhydrobiotic eggs of the Tardigrade ramazzottius varieornatus to extreme environments. Horikawa D D, Yamaguchi A, Sakashita T, Tanaka D, Hamada N, Yukuhiro F, Kuwahara H, Kunieda T, Watanabe M, Nakahara Y, Wada S, Funayama T, Katagiri C, Higashi S, Yokobori S, Kuwabara M, Rothschild L J, Okuda T, Hashimoto H and Kobayashi Y, Astrobiology, 12(4), 283-289, 2012.

Relaxation Behaviors of Free Radicals from γ-Irradiated Black Pepper using Pulsed EPR Spectroscopy. Kameya H, Kikuchi M, Hara H, Furuta M, Todoriki S, Kobayashi Y, Ukai M and Shimoyama Y, Applied Magnetic Resonance, 42(2), 153-159, 2012

Evaluation of the relative biological effectiveness of carbon ion beams in the cerebellum using the rat organotypic slice culture system. Yoshida Y, Suzuki Y, Al-Jahdari W S, Hamada N, Funayama T, Shirai K, Katoh H, Sakashita T, Kobayashi Y & Nakano T, J Radiat Res, 53(1), 87-92, 2012.

2011

ESR detection procedure of irradiated papaya containing high water content. Kikuchi M, Shimoyama Y, Ukai M, Kobayashi Y, Radiat Phys Chem, 80, 664-667, 2011.

Radiation-induced ICAM-1 expression via TGF-β1 pathway on human umbilical vein endothelial cells; comparison between X-ray and carbon-ion beam irradiation. Kiyohara H, Ishizaki Y, Suzuki Y, Katoh H, Hamada N, Ohno T,Takahashi T, Kobayashi Y, Nakano T, J Radiat Res, 52(3), 287-291, 2011.

Monte carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths. Watanabe R, Wada S, Funayama T, Kobayashi Y, Saito K and Furusawa Y, Radiat Prot Dosimetry, 43(2-4), 186-190, 2011.

2010

Anhydrobiosis-associated nuclear DNA damage and repair in the Sleeping Chironomid: linkage with radioresistance. O. Gusev, Y. Nakahara, V. Vanyagina, L. Malutina, R. Cornette, T. Sakashita, N. Hamada, T. Kikawada, M. Fujita, Y. Kobayashi and T. Okuda., PLoS ONE, e14008, 2010

Enhanced micronucleus formation in the descendants of gamma-ray-irradiated tobacco cells: Evidence for radiation-induced genomic instability in plant cells. Y. Yokota, T. Funayama, Y. Hase, N. Hamada, Y. Kobayashi, A. Tanaka and I. Narumi, Mutat. Res.-Fundam. Mol. Mech. Mutagen. 691, 41-46, 2010. (doi: 10.1016/j.mrfmmm.2010.07.001).

ESR Study of Free Radicals in Mango. Masahiro KIKUCHI, Mohammad S. HUSSAIN, Norio MORISHITA, Mitsuko UKAI, Yasuhiko KOBAYASHI and Yuhei SHIMOYAMA, Spectrochim Acta Part A, 75(1), 310-313, 2010.

Irradiation with carbon ion beams induces apoptosis, autophagy, and cellular senescence in a human glioma-derived cell line. Jinno-Oue A, Shimizu N, Hamada N, Wada S, Tanaka A, Shinagawa M, Ohtsuki T, Mori T, Saha MN, Hoque, AS, Islam S, Kogure K, Funayama T, Kobayashi Y, Hoshino H, Int. J. Radiat. Oncol. Biol. Phys. 76(1), 229-241, 2010.

2009

The radiobiological effectiveness of carbon-ion beams on growing neurons. Al-Jahdari W S, Suzuki Y, Yoshida Y, Hamada N, Shirai K, Noda S, Funayama T, Sakashita T, Kobayashi Y, Saito S, Goto F and Nakano T, Int J Radiat Biol, 85(8), 700-709, 2009.

Targeted Heavy-Ion Microbeam Irradiation of the Embryo But Not Yolk in the Diapause-Terminated Egg of the Silkworm, Bombyx mori, Induces The Somatic Mutation. Toshiharu FURUSAWA, Kana FUKAMOTO, Tetsuya SAKASHITA, Eiko SUZUKI, Takehiko KAKIZAKI, Nobuyuki HAMADA, Tomoo FUNAYAMA, Hiromi SUZUKI, Noriaki ISHIOKA, Seiichi WADA, Yasuhiko KOBAYASHI and Shunji NAGAOKA, J. Radiat. Res. 50(4), 371-375, 2009.

Kinetic analysis of double-strand break rejoining reveals the DNAreparability of gamma-irradiated tobacco cultured cells. YuichiroYokota, Seiichi Wada, Yoshihiro Hase, Tomoo Funayama, YasuhikoKobayashi, Issay Narumi, and Atsushi Tanaka, J. Radiat. Res. 50(2), 170-175, 2009.

Ceramide induces myogenic differentiation and apoptosis in Drosophila Schneider cells. Hidemasa Kawamura, Kazuaki Tatei, Tetsuo Nonaka, HideruObinata, Tomoyasu Hattori, Ai Ogawa, Hideko Kazama, Nobuyuki Hamada,Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Takashi Nakano,and Takashi Izumi, J. Radiat. Res., 50(2), 161-169, 2009.

Effects of Ionizing Radiation on Locomotory Behavior andMechanosensation in Caenorhabditis elegans. Michiyo Suzuki,Tetsuya Sakashita, Sumino Yanase, Masahiro Kikuchi, HirofumiOhba, Atsushi Higashitani, Nobuyuki Hamada, Tomoo Funayama, Kana Fukamoto, Toshio Tsuji, and Yasuhiko Kobayashi, J. Radiat. Res. 50(2), 119-125, 2009.

Microbeam Irradiation Facilities for Radiobiology in Japan and China. Yasuhiko KOBAYASHI, Tomoo FUNAYAMA, Nobuyuki HAMADA, Tetsuya SAKASHITA, Teruaki KONISHI, Hitoshi IMASEKI, Keisuke YASUDA, Masanori HATASHITA, Keiichi TAKAGI, Satoshi HATORI, Keiji SUZUKI, Motohiro YAMAUCHI, Shunichi YAMASHITA, Masanori TOMITA, Munetoshi MAEDA, Katsumi KOBAYASHI, Noriko USAMI and Lijun WU, J. Radiat. Res., 50: Suppl., A29-A47, 2009.

Expanding the Question-answering Potential of Single-cell Microbeams at RARAF, USA. Bigelow A, Garty G, Funayama T, Randers-Pehrson G, Brenner D & Geard C, J. Radiat. Res., 50: Suppl., A21-A28, 2009.

Insufficient membrane fusion in dysferlin-deficient muscle fibers after heavy-ion irradiation. Mizuki Hino, Nobuyuki Hamada, Yuki Tajika, Tomoo Funayama, Yoshihiro Morimura, Tetsuya Sakashita, Yuichiro Yokota, Kana Fukamoto, Yasuhiko Kobayashi, and Hiroshi Yorifuji, Cell Struct. Funct. 34, 11-15, 2009.

Heavy-ion induced bystander killing of human lung cancer cells: the role of gap junctional intercellular communication. Kosaku Harada, Tetsuo Nonaka, Nobuyuki Hamada, Hideyuki Sakurai, Masatoshi Hasegawa, Tomoo Funayama, Takehiko Kakizaki, Yasuhiko Kobayashi, and Takashi Nakano, Cancer Sci. 100(4), 684-688, 2009.

Status of food irradiation in the world. Tamikazu Kume, Masakazu Furuta, Setsuko Todoriki, Naoki Uenoyama and Yasuhiko Kobayashi, Radiat. Phys. Chem. 78, 222-226, 2009.

Quantity and Economic Scale of Food Irradiation in the World. Tamikazu Kume, Masakazu Furuta, Setsuko Todoriki, Naoki Uenoyama and Yasuhiko Kobayashi, RADIOISOTOPES, 58(1), 25-35, 2009.

No evidence for DNA and early cytogenetic damage in bystander cells following heavy ion micro-irradiation at two facilities. Claudia Fournier, Philippe Barberet, Thomas Pouthier, Sylvia Ritter, Bernd Fischer, Kay-Obbe Voss, Tomoo Funayama, Nobuyuki Hamada, Yasuhiko Kobayashi, and Gisela Taucher-Scholz, Radiat Res. 171, 530-540, 2009.

2008

A LET-dependent decrease in the apoptotic response of normal human fibroblast cultures to isosurvival doses of gamma-rays and energetic heavy ions. Nobuyuki Hamada, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: 41-45, 2008.

Heavy-ion microbeam irradiation induces bystander killing of human cells. Nobuyuki Hamada, Takamitsu Hara, Motoko Omura-Minamisawa, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: 46-53, 2008.

Exposure of normal human fibroblasts to heavy-ion radiation promotes their morphological differentiation. Sakura Sora, Nobuyuki Hamada, Takamitsu Hara, Tomoo Funayama, Tetsuya Sakashita, Yuichiro Yokota, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: 54-58, 2008.

The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation. Nobuyuki Hamada, Keiko Kataoka, Sakura Sora, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Takashi Nakano, and Yasuhiko Kobayashi. Radiother. Oncol. 89: 227-230, 2008.

Energetic heavy ions overcome tumor radioresistance caused by overexpression of Bcl-2. Nobuyuki Hamada, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Yuichiro Yokota, Takashi Nakano, and Yasuhiko Kobayashi. Radiother. Oncol. 89: 231-236, 2008.

The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny. Nobuyuki Hamada, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Cancer Lett. 268: 76-81, 2008.

A LET-dependent decrease in the apoptotic response of normal human fibroblast cultures to isosurvival doses of gamma-rays and energetic heavy ions. Nobuyuki Hamada, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: in press, 2008.

Establishment of a rearing system of the extremotolerant tardigradeRamazzottius varieornatus: a new model animal for astrobiology. Daiki D.Horikawa, Takekazu Kunieda, Wataru Abe, Masahiko Watanabe, Yuichi Nakahara,Fumiko Yukuhiro, Tetsuya Sakashita, Nobuyuki Hamada, Seiichi Wada, TomooFunayama, Chihiro Katagiri, Yasuhiko Kobayashi, Seigo Higashi, and TakashiOkuda. Astrobiology, 8: 557-568, 2008.

Effects of Locally Targeted Heavy-ion and Laser Microbeam on RootHydrotropism in Arabidopsis thaliana. Yutaka Miyazawa, Tetsuya Sakashita,Tomoo Funayama, Nobuyuki Hamada, Hiroshi Negishi, Akie Kobayashi, TomokoKaneyasu, Atsushi Ooba, Keita Morohashi, Takehiko Kakizaki, Seiichi Wada,Yasuhiko Kobayashi, Nobuharu Fujii, and Hideyuki Takahashi. J. Radiat. Res.49: 373-379, 2008.

Expression profiles are different in carbon ion-irradiated normal humanfibroblasts and their bystander cells. Mayumi Iwakawa, Nobuyuki Hamada,Kaori Imadome, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, andTakashi Imai. Mutat. Res. 642: 57-67, 2008.

Proliferation and cell death of human glioblastoma cells after carbon-ion beam exposure: morphologic and morphometric analyses. Takuma Oishi, Atsushi Sasaki, Nobuyuk Hamada, Shogo Ishiuchi, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Takashi Nakano, and Yoichi Nakazato. Neuropathology 28: 408-416, 2008.

Locomotion – learning behevior relationship in Caenorhabditis elegans following gamma-ray irradiation. Tetsuya Sakashita, Nobuyuki Hamada, Daisuke D. Ikeda, Michiyo Suzuki, Sumino Yanase, Naoaki Ishii, and Yasuhiko Kobayashi. J. Radiat. Res. 49: 285-291, 2008.

Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions. Nobuyuki Hamada, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Mutat. Res. 639: 35-44, 2008.

Modulatory effect of ionizing radiation on food-NaCl associative learning: The role of γ subunit of G protein in Caenorhabditis elegans. Tetsuya Sakashita, Nobuyuki Hamada, Daisuke D. Ikeda, Sumino Yanase, Michiyo Suzuki, Naoaki Ishii and Yasuhiko Kobayashi, FASEB J. 22:713-720, 2008.

Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts. Nobuyuki Hamada, Takamitsu Hara, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Mutat. Res. 637: 190-196, 2008.

Heavy-ion microbeam system at JAEA-Takasaki for Microbeam Biology. Tomoo Funayama, Seiichi Wada, Yuichiro Yokota, Kana Fukamoto, Tetsuya Sakashita Mitsumasa Taguchi, Takehiko Kakizaki, Nobuyuki Hamada, Michiyo Suzuki, Yoshiya Furusawa, Hiroshi Watanabe, Kenji Kiguchi, and Yasuhiko Kobayashi, J. Radiat. Res. 49: 71-82, 2008.

2007

Effects of γ-ray irradiation on olfactory adaptation to benzaldehyde in Caenorhabditis elegans, Sakashita T, Hamada N, Suzuki M, Ikeda DD, Yanase S, Ishii N, Kobayashi Y, Biological Sciences in Space 21:117-120, 2007.

The effects of ultraviolet irradiation and hypoxia on expression of glutathione peroxidase and glyceraldehyde 3-phosphate dehydrogenase in the cultured retinal pigment epithelium. Kiyoshi Akeo, Tomoo Funayama, Nobuyuki Hamada, Yoko Akeo, Tadahisa Hiramitsu, and Yasuhiko Kobayashi. Tissue Cult. Res. Commun., 26: 149-157, 2007.

Chemiluminescence ELISA for the detection of oxidative DNA base damage using anti-8-hydroxy-2'-deoxyguanosine antibody: application to the detection of irradiated foods. Masahiro KIKUCHI, Chaminda R. GUNAWARDANE, Md. Khorshed ALAM, A. Zainuri Mohd. DZOMIR, Ramya C. Pitipanaarachchi, Tomoo FUNAYAMA, Nobuyuki HAMADA, Tetsuya SAKASHITA, Seiichi WADA, Katsuya SATOH, Issay NARUMI and Yasuhiko KOBAYASHI, RADIOISOTOPES 56: 509-517, 2007

Heavy Ion Microbeam Irradiation Induces Ultrastructural Changes in Isolated Single Fibers of Skeletal Muscle. Hino M., Wada S., Tajika Y., Morimura Y., Hamada N., Funayama T., Sakashita T., Kakizaki T., Kobayashi Y. and Yorifuji H. Cell Struct. Funct. 32: 51-56, 2007.

Physiological changes leading to anhydrobiosis improve radiation tolerance in Polypedilum vanderplanki larvae. Watanabe M., Nakahara Y., Sakashita T., Kikawada T., Fujita A., Hamada N., Horikawa D. D., Wada S., Kobayashi Y., Okuda T. J. Insect Physiology 53(6), 573-579, 2007

Vulnerability of feline T-lymphocytes to charged particles. Kakizaki T., Hamada N., Sakashita T., Wada S., Hara T., Funayama T., Hohdatsu T., Natsuhori M., Sano T., Kobayashi Y., and Ito N. J. Vet. Med. Sci. 48: 97-106, 2007.

Development of the Irradiation Method for the First Instar Silkworm Larvae Using Locally Targeted Heavy-ion Microbeam. Fukamoto K., Shirai K., Sakata T., Sakashita T., Funayama T., Hamada N., Wada S., Kakizaki T., Shimura S., Kobayashi Y. and Kiguchi K. J. Radiat. Res. 48, 247-253, 2007

Role of DNA-PKcs in the bystander effect after low- or high-LET irradiation. Kanasugi Y, Hamada N., Wada S., Funayama T., Sakashita T., Kakizaki T., Kobayashi Y., Takakura K. Int. J. Radiat. Biol. 83: 73-80, 2007.

2006

Estimation of radiation tolerance against high LET heavy ions in an anhydrobiotic insect, Polypedilum vanderplanki. Watanabe M., Sakashita T., Fujita A., Kikawada T., Nakahara Y., Hamada N., Horikawa D.D., Wada S., Funayama T., Kobayashi Y., Okuda T. Int. J. Radiat. Biol. 82: 835-842, 2006.

Radiation tolerance in the tardigrade Milnesium tardigradum. Horikawa D.D., Sakashita T., Katagiri C., Watanabe M., Kikawada T., Nakahara Y., Hamada N., Wada S., Funayama T., Higashi S., Kobayashi Y., Okuda T., Kuwabara M. Int. J. Radiat. Biol. 82: 843-848, 2006.

Killing of Feline T-Lymphocytes by Gamma-Rays and Energetic Carbon Ions. Kakizaki T., Hamada N., Funayama T., Sakashita T., Wada S., Hohdatsu T., Natsuhori M., Sano T., Kobayashi Y., Ito N. J. Vet. Med. Sci. 68: 1269-1273, 2006.

Distinct Modes of Cell Death by Ionizing Radiation Observed in Two Lines of Feline T-Lymphocytes. Kakizaki T., Hamada N., Wada S., Funayama T., Sakashita T., Hohdatsu T., Sano T., Natsuhori M., Kobayashi Y., Ito N. J. Radiat. Res. 47(3-4):237-243, 2006.

Process of in vivo cyst formation from the implanted larval integument in the sweet potato hornworm, Agrius convolvuli: A simple model for studying wound healing. Fukamoto K., Shirai K., Sato S., Kanekatsu R., Kiguchi K., Kobayashi Y. J. Insect Baiotechnol. Sericol. 75:99-106, 2006.

Effects of heavy-ion irradiation on the differentiation of epidermal cells in the silkworm, Bombyx mori. Fukamoto K., Shimura S., Shirai K., Kanekatsu R., Kiguchi K., Sakashita T., Funayama T., Kobayashi Y. J. Insect Baiotechnol. Sericol. 75:107-114, 2006.

Biological effects of anhydrobiosis in an African chironomid, Polypedilum vanderplanki on radiation tolerance. Watanabe M., Sakashita T., Fujita A., Kikawada T., Horikawa D.D., Nakahara Y., Wada S., Funayama T., Hamada N., Kobayashi Y., Okuda T. Int. J. Radiat. Biol. 82:587-592, 2006.

Effects of gamma irradiation on bcl-2 and p53 expression in the porcine ciliary body. Akeo K., Funayama T., Ogawa A., Hamada N., Akeo Y., Kobayashi Y. Exp. Anim. 55(4):375-381, 2006.

LET-Dependent Survival of Irradiated Normal Human Fibroblasts and Their Descendents. Hamada N., Funayama T., Wada S., Sakashita S., Kakizaki T., Ni M., Kobayashi Y. Radiat. Res. 166:24-30, 2006.

Differential effects of x-irradiation on immature and mature hippocampal neurons in vitro. Shirai K., Mizui T., Suzuki Y., Kobayashi Y., Nakano T., Shirao T. Neuroscience Letters 399:57-60, 2006.

Method for detecting DNA strand breaks in mammalian cells using the Deinococcus radiodurans PprA protein. Satoh K, Wada S, Kikuchi M, Funayama T, Narumi I, Kobayashi Y. Mutat. Res. 596:36-42, 2006.

Cell cycle arrest and apoptosis in Caenorhabditis elegans germline cells following heavy-ion microbeam irradiation. Sugimoto T., Dazai K., Sakashita T, Funayama T., Wada S., Hamada N., Kakizaki T., Kobayashi Y., Higashitani A. Int. J. Radiat. Biol. 82:31-38, 2006.

Contribution of circulating hemocytes to the regeneration of heavy ion beams (12C5+) irradiated hematopoietic organs in the silkworm, Bombyx mori, through the way of phagocytosis of injured cells after invasion. Ling E., Shirai K., Kanekatsu R., Kiguchi K., Kobayashi Y., Funayama T. Watanabe H. Developmental & Comparative Immunology 30(6):531-543, 2006.

2005

Exploration of 'Over Kill Effect' of High-LET Ar- and Fe-ions by Evaluating the Fraction of Non-hit Cell and Interphase Death. Mehnati P., Morimoto S., Yatagai F., Furusawa Y., Kobayashi Y., Wada S., Kanai T., Hanaoka F. and Sasaki H. J. Radiat. Res. 46(3):343-350, 2005.

Comparative radiation tolerance based on the induction of DNA double-strand breaks in tobacco BY-2 cells and CHO-K1 cells irradiated with gamma rays. Yokota Y, Shikazono N, Tanaka A, Hase Y, Funayama T, Wada S, Inoue M. Radiat. Res. 163:520-525, 2005.

Irradiation of mammalian cultured cells with collimated heavy ion microbeam. Funayama T., Wada S., Kobayashi Y., Watanabe H. Radiat. Res. 163:241-246, 2005.

Characterization of pathways dependent on the uvsE, uvrA1, or uvrA2 gene product for ultraviolet resistance in Deinococcus radiodurans. Tanaka M, Narumi I, Funayama T, Kikuchi M, Watanabe H, Matsunaga T, Nikaido O, Yamamoto K. J. Bacteriol. 187:3693-3697, 2005.

Prediction of Cellular Radiosensitivity from DNA Damage Induced by ƒÁ-Rays and Carbon Ion Irradiation in Canine Tumor Cells. Wada S., Khoa T.V., Kobayashi Y., Funayama T., Ogihara K., Ueno S., Ito N. J. Vet. Med. Sci. 67(11):1089-1095, 2005.

2004

Light dependency of resistance to ionizing radiation in Euglena gracilis. Hayashi H, Narumi I, Wada S, Kikuchi M, Furuta M, Uehara K, Watanabe H. J. Plant Physiol. 161:1101-1106, 2004.

PprA: a novel protein from Deinococcus radiodurans that stimulates DNA ligation. Narumi I, Satoh K, Cui S, Funayama T, Kitayama S, Watanabe H. Mol. Microbiol. 54:278-285, 2004.

Evaluation of the resistance of Euglena gracilis to ion beam radiation. Hayashi H, Wada S, Funayama T, Narumi I, Kobayashi Y, Watanabe H, Furuta M, Uehara K. J. Eukaryot. Microbiol. 51:321-324, 2004.

2003

Development of an ion microbeam system for irradiating single plant cell[s]. Yokota Y, Funayama T, Kobayashi Y, Sakashita T, Wada S, Hase Y, Shikazono N, Tanaka A, Inoue M. Biol. Sci. Space 17:298-301, 2003.

Detection of Radiation-Induced Apoptosis Using the Comet Assay. Wada S., Khoa T.V., Kobayashi Y., Funayama T., Yamamoto K., Natsuhori M., Ito N. J. Vet. Med. Sci. 65(11):1161-1166, 2003.

Bystander effect induced by counted high-LET particles in confluent human fibroblasts: A mechanistic study. Shao C., Furusawa Y., Kobayashi Y., Funayama T., Wada S. The FASEB Journal 17:1422-1427, 2003.

Regeneration of hemopoietic organs in the silkworm, Bombyx mori, after locally targeted irradiation with heavy ion beams. Ling E., Fukamoto K., Xu S., Shirai K., Kanetatsu R., Kobayashi Y., Tu Z.L., Funayama T., Watanabe H., Kiguchi K. J. Insect Biotechnol. Sericol. 72(2): 95-100, 2003.

Why does hemocyte density rise during the wandering stage of the silkworm, Bombyx mori? Ling E., Shirai K., Kanetatsu R., Kobayashi Y., Tu Z.L., Funayama T., Watanabe H., Kiguchi K. J. Insect Biotechnol. Sericol. 72(2):101-109, 2003.

The Relationship between Cellular Radiosensitivity and Radiation-Induced DNA Damage Measured by the Comet Assay. Wada S., Kurahashi H., Kobayashi Y., Funayama T., Yamamoto K., Natsuhori M., Ito N. J. Vet. Med. Sci.i 65(4):471-477, 2003.

Irradiation of single mammalian cells with a precise number of energetic heavy ions - Applications of microbeams for studying cellular radiation response. Kobayashi Y., Funayama T., Wada S., Taguchi M., Watanabe H. Nucl. Inst. and Methods in Phys. Res., B210:308-311, 2003.

Radiosurgery using heavy ion microbeams for biological study: Fate mapping of the cellular blastderm-stage egg of the silkworm, Bombyx mori. Kiguchi K., Shirai K., Kanekatsu R., Kobayashi Y., Tu Z.L., Funayama T., Watanabe H. Nucl. Inst. and Methods in Phys. Res., B210:312-315, 2003.

Detection of DNA damage induced by heavy ion irradiation in the individual cells with comet assay. Wada S., Natsuhori M., Ito N., Funayama T., Kobayashi Y. Nucl. Inst. and Methods in Phys. Res., B206:553-556, 2003.

Irradiation effect of different heavy ions and track section on the silkworm Bombyx mori. Tu Z.L., Kobayashi Y., Kiguchi K., Watanabe H. Nucl. Inst. and Methods in Phys. Res., B206:591-595, 2003.

 

Review

Recent Advances in the Biology of Heavy-Ion Cancer Therapy. Nobuyuki HAMADA, Tatsuhiko IMAOKA, Shin-ichiro MASUNAGA, Toshiyuki OGATA, Ryuichi OKAYASU, Akihisa TAKAHASHI, Takamitsu A. KATO, Yasuhiko KOBAYASHI, Takeo OHNISHI, Koji ONO, Yoshiya SHIMADA and Teruki TESHIMA, J Radiat Res, 51(4), 365-383, 2010.

REVIEW: Radiation biology of Caenorhabditis elegans: Germ cell response, aging and behavior. Tetsuya SAKASHITA, Takako TAKANAMI, Sumino YANASE, Nobuyuki HAMADA, Michiyo SUZUKI, Takafumi KIMURA, Yasuhiko KOBAYASHI, Naoaki ISHII and Atsushi HIGASHITANI, J Radiat Res, 51(2), 107-121, 2010.

Heavy-ion microbeams – development and applications in biological studies.Tomoo Funayama, Nobuyuki Hamada, Tetsuya Sakashita, Yasuhiko Kobayashi. IEEE Trans. Plasma Sci. 36: 1432-1440, 2008.

Intercellular and Intracelllar Signaling Pathways Mediating Ionising Radiation-Induced Bystander Effects. Hamada N., Matsumoto H., Hara T., Kobayashi Y. J. Radiat. Res. 48: 87-95, 2007.

Vanguards of paradigm shift in radiation biology: Radioadaptive response and radiation-induced bystander response.Matsumoto H., Hamada N., Takahashi A., Kobayashi Y., Ohnishi T. J. Radiat. Res. 48: 97-106, 2007.

Microbeams of heavy charged particles. Kobayashi Y., Funayama T., Wada S., Furusawa Y., Aoki M., Shao C., Yokota Y., Sakashita T., Matsumoto Y., Kakizaki T., Hamada N. Biol. Sci. Space 18:235-240, 2004.

Project TopDepartment TOP